Notice Regarding Change in Major Shareholders

Key Points of Change in Major Shareholders

Following the submission of a revised large-shareholding report to the Kanto Local Finance Bureau dated October 27, 2026, a change in KYORIN Pharmaceutical Co., Ltd.'s major shareholders has been confirmed. Kopernik Global Investors, LLC has been newly identified as a relevant shareholder; the number of voting rights after the change is 60,512 units, and the proportion of total shareholders' voting rights rose to 10.44%. It is noted that a definitive confirmation of the substantive change in the number of shares held before and after the change has not been established. There are no special statements regarding the future outlook.

Impact on Shareholder Composition and Points to Watch

The revised large-shareholding report reveals the emergence of a new major shareholder, indicating changes in shareholder composition including potential long-term holdings and strategic influence by institutional investors. Although there are limitations in confirming the substantive number of shares held, the voting rights ratio has increased into the 10% range. Going forward, attention should be paid to additional changes in holding status and trends in the allocation of voting rights in future disclosures.