Regarding Matters Concerning the Controlling Shareholder

Status of Parent Company and Controlling Shareholders

Kyowa Kirin Co., Ltd.'s parent company is Kirin Holdings Company, Limited, which held 55.22% of voting rights as of December 31, 2025. Kirin Holdings is listed on the Tokyo Stock Exchange Prime Market and other exchanges. Under the Kirin Group’s long-term management vision 'KV2027' and the new 'Innovate2035!' initiative, our company is responsible for the pharmaceutical domain and aims to create value as a Japan-originated global specialty pharma.

Relationship with Parent Company and Ensuring Independence

While utilizing the know-how and expertise of the Kirin Group, our company maintains management independence. Loan transactions are determined rationally with consideration of market interest rates. To address conflict of interest risks, officers concurrently serving in the parent company do not participate in related deliberations, and we have established a Nomination and Remuneration Advisory Committee and a Conflict of Interest Oversight Committee, both with a majority of independent outside directors. In fiscal year 2025, there were no significant conflict of interest deliberations.